There is no highly effective vaccine against tuberculosis (TB), which remains an infection of global concern. Charles ...

A decades-old TB vaccine turned cancer therapy may unlock new immunotherapies by reprogramming immune cell development in the ...

The rod-shaped tuberculosis (TB) bacterium, which the World Health Organization has once again ranked as the top infectious disease killer globally, is the first single-celled organism ever observed ...

This discovery highlights a previously unrecognized way antibodies can work against TB not merely by neutralizing pathogens directly, but by reshaping immune cell functions within infected tissues ...

the causative agent of tuberculosis. In 2023, TB made 10.8 million people sick and killed around 1.25 million people. “The most fundamental things you can ask of a bacterium: How does it grow and ...

Singleron Biotechnologies today announced the launch of MobiuSCOPE, a single cell RNA sequencing kit that provides full-length transcript analysis using standard short-read sequencing. Founded in 2018 ...

For this, they sorted out MR1T cells and performed single-cell RNA sequencing ... MR1-restricted T cell clonotypes are associated with "resistance" to Mycobacterium tuberculosis infection. JCI Insight ...

Xin Wang et al, Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models, Nature Microbiology (2025). DOI: 10.1038/s41564-024-01913-5 ...

Time-lapse analyses of millions of antibiotic-stressed Escherichia coli characterize the diverse single-cell dynamics of persister cells that depend on antibiotics, culture conditions, and ...

Analyzing the gene activity of every single bacterial cell in a colony? A new technique from Würzburg can do this much more efficiently than other methods. Not all individuals in a population of ...