These symptoms occur when mast cells are activated by IgE class antibodies during repeated antigen contact. "Why mast cells and IgE exist at all has not yet been conclusively explained," says Hans ...

Mast cells have diverse phenotypes depending on the tissue of residence. Those in the lung of individuals with atopy express Immunoglobulin E (IgE) receptor, FcεR1 at higher levels relative to ...

The classic trigger for that activation is the binding of a form of circulating antibody, or immunoglobin, called IgE to specialized receptors abounding on mast cells. The evolutionary purpose of ...

This inspired our research team to investigate the role of mucosal mast cells in the pathogenesis of food allergy," says Nakano, sharing the motivation behind the present research.

Related Content “Taken together, the results indicate crosstalk between immune cells resulting in IgE independent mast cell specific allergic inflammation,” the authors concluded. They added ...

There were no serious adverse events (SAEs) There were no treatment emergent adverse events leading to discontinuation of AK006 There were no dose limiting toxicities The most common adverse ...

Secondary MCAS is when the mast cells are inappropriately triggered/over-activated by certain IgE antibodies or by certain stressors (for example, certain drugs, physical activity, stress ...

Dr Conor Finlay, a scientist from the Trinity Translational Medicine Institute (TTMI) and one of the senior authors of the study, said: "Mast cells pack a punch, when activated by IgE antibodies ...

These symptoms occur when mast cells are activated by IgE class antibodies during repeated antigen contact. "Why mast cells and IgE exist at all has not yet been conclusively explained," says Hans ...