On subsequent encounter with the drug, a hapten–carrier complex is formed again, which then crosslinks preformed drug-specific IgE on mast cells, activating a cascade for allergic reaction.

Mast cells preform and store approximately 500 secretory granules and many others which are made de novo and are released locally and in systemic circulation when specific antigens react with IgE ...

Now, a new study by scientists from Juntendo University, Japan, reveals the role of major histocompatibility complex class II (MHCII)-expressing mucosal mast cells in IgE-mediated food allergy.

This inspired our research team to investigate the role of mucosal mast cells in the pathogenesis of food allergy," says Nakano, sharing the motivation behind the present research.

Key Points 1. Plasmacytoid dendritic cells (pDC) are a unique subset of antigen-presenting cells known to be involved in innate immunity, cancer, and immune tolerance. 2. It is not clear why pDC ...

Emerging research shows mast cells play a role in the etiology of chronic rhinosinusitis with nasal polyps and may be a new treatment target for the condition.

MCAS is a rare disorder in which your mast cells release too many chemicals, triggering allergic symptoms sometimes even when no known allergen is present.

Scientists were able to treat a "macular hole" in a monkey, helping to restore the animal's vision thanks to human stem cells.

The elevation of pathologic IgE and over-reactive mast cells/basophils is a central factor in food allergy anaphylaxis. This study aims to comprehensively evaluate the potential therapeutic mechanisms ...

--Allakos Inc., a biotechnology company developing AK006 for the treatment of mast cell-driven diseases, today announced positive results from the single and multiple ascending Phase 1 study of ...

The origin of the mast cells is therefore of importance when setting up a model system, and human lung mast cells are highly relevant cells to study in the context of asthma. We therefore set out to ...