Transcription factors bind in a combinatorial fashion to specify the on-and-off states of genes; the ensemble of these binding events forms a regulatory network, constituting the wiring diagram ...

It found that cooperation between multiple transcription factors is a key feature of transcription factor-DNA binding, with DNA actively facilitating interactions between various transcription ...

“Together with Roche's expertise, our objective is to successfully pursue challenging transcription factor targets, with the ultimate goal of providing novel interventions for patients who are ...

"This study uncovered a complex layer of antiviral defense involving RNA editing, RNAi, and transcription start site switching, closely linked to transcription reprogramming to regulate symptom ...

Transcription factor ADs are encoded by a wide range of seemingly unrelated amino acid sequences, and are structurally disordered, leaving the question open of how their unusual properties translate ...

The transcription factor CDX2—which plays an important role in the development and function of the digestive system—is a key mediator of these differences in proximal (right) colon stem cells ...

The transcription factor FOXA1 has been one of the most coveted targets for a drug because it is implicated in the growth of breast and prostate cancers, according to Erb. Erb’s lab, in ...

Randomized Phase II Study of Pulse Erlotinib Before or After Carboplatin and Paclitaxel in Current or Former Smokers With Advanced Non–Small-Cell Lung Cancer Thyroid transcription factor 1 (TTF1) is a ...