Genetic alterations that have been studied for use in personalizing cancer medicine include: CYP polymorphisms, UGT1A1 polymorphisms, thiopurine methyltransferase (TPMT) polymorphisms ...

A RECENT study suggests that adding allopurinol to maintenance therapy for paediatric acute lymphoblastic leukaemia (ALL) can improve treatment outcomes and reduce toxicity, even in patients without ...

Thiopurine S-methyltransferase (TPMT) modulates the cytotoxic effects of thiopurine prodrugs such as 6-mercaptopurine by methylating them in a reaction using S-adenosyl-l-methionine as the donor.

Acute lymphoblastic leukemia (ALL), sometimes known as acute lymphocytic leukemia, is a rare malignancy of B or T lymphocytes characterized by the uncontrolled proliferation of immature B or T cells ...

Because a thiopurine methyltransferase assay showed intermediate activity, which indicated a potentially increased risk of myelosuppression with azathioprine, she received a low dose of 100 mg daily.

For instance, Thiopurine methyltransferase (TPMT) test for individuals applying for thiopurine medication therapy shows that for some autoimmune conditions, such as Crohn’s disease and rheumatoid ...

Variations in the thiopurine S-methyltransferase (TPMT) gene are widely associated with an increased incidence of thiopurine-associated myelotoxicity (6). Despite that thiopurine-induced myelotoxicity ...

Azathioprine oral tablet is a prescription medication used to treat rheumatoid arthritis. It's also used after a kidney transplant. It's available as a generic drug and as the brand-name drugs ...

Thiopurine S-methyltransferase (TPTM) is a well known biomarker for thiopurine-induced leucopenia, which has limited value in Asia. Instead, NUDT15 C415T is a promising predictor in Asia.To explore ...

PURPOSE: To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), and to evaluate their ...