The field of pharmacogenetics has revealed that genetic variations, particularly in key enzymes such as thiopurine S‐methyltransferase (TPMT) and nucleotide diphosphate-linked moiety X-type ...

The American College of Gastroenterology (ACG) has issued updated guidance on the management of Crohn’s disease (CD) that reflects the surge in development of therapeutic options available since ...

Genetic alterations that have been studied for use in personalizing cancer medicine include: CYP polymorphisms, UGT1A1 polymorphisms, thiopurine methyltransferase (TPMT) polymorphisms ...

Azathioprine and its metabolite 6-mercaptopurine (6-MP) are widely used in the treatment of Crohn’s disease, ulcerative colitis, autoimmune hepatitis, and a range of other inflammatory and autoimmune ...

Shared mechanisms of METTL3 and METTL14 in heart development and sarcomere gene regulation through methyltransferase activity. A and B, Immunofluorescence staining demonstrated effective deletion of ...

Following a prolonged period of relative inertia, real progress has been made in the past few years in understanding the pathogenesis of the chronic inflammatory bowel diseases, Crohn's disease and ...

Indeed, there is already application of pharmacogenomic research in paediatric oncology practice in the UK, with treatment of acute lymphoblastic leukaemia using the standard treatment protocol (UKALL ...

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ABSTRACT GENETICS Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris Lin Gao 1 * Hong Li 1 * Kai Li 1 * Zhu Shen 1 Ling Liu 1 Chunying Li 1 Zhengdong ...

Herein, a hand-drawing paper-based bipolar electrode (BPE) electrochemiluminescence (ECL) platform for M.SssI methyltransferase (M.SssI MTase) assay was proposed via employing high electrocatalytic Pt ...