Classic pharmacogenetic traits: the thiopurine S-methyltransferase polymorphism (A) Cytochrome P450 2D6 (CYP2D6) pharmacogenetics determined using the ratio of debrisoquine to its metabolite, 4 ...

There is a lack of research describing the associations between thiopurine methyltransferase (TPMT)/inosine triphosphate pyrophosphatase (ITPA) genotypes and long-term clinical outcomes. We ...

PURPOSE: To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), and to evaluate their ...

What is the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing of thiopurine drugs in clinical practice? Six economic models were identified and appraised.

The FDA has issued a safety alert warning patients and health care providers of a “rare risk of intrahepatic cholestasis of pregnancy” linked to thiopurine use. The safety alert follows ...

The combination therapy of allopurinol and thiopurine can be safe and effective in patients with IBD who have not been responsive to prior thiopurine monotherapy, according to recent study results.

Background: The effect of thiopurine immunomodulators on health-related quality of life (HRQoL) in patients with inflammatory bowel disease (IBD) has been controversial. The aims were to evaluate ...