PURPOSE: To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), and to evaluate their cl ...

The common treatment of acute lymphoblastic leukemia (ALL) is based on induction remission therapy followed by intensification and maintenance therapy 1 which consists of administration of daily ...

This ongoing study uses minimal residual disease analysis at two follow-up points, to facilitate risk-adapted treatment stratification in ALL patients aged 1–18 years. In the current analysis, 814 ...

This study aimed to critically appraise the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing of thiopurine drugs, such as azathioprine. Six economic ...

Please provide your email address to receive an email when new articles are posted on . The FDA has issued a safety alert warning patients and health care providers of a “rare risk of intrahepatic ...

Patients with inflammatory bowel diseases (IBDs) such as Crohn's disease or ulcerative colitis do perceive a benefit from thiopurine treatment. A new study demonstrates improved health-related quality ...

Comparison of Oral Capecitabine Versus Intravenous Fluorouracil Plus Leucovorin as First-Line Treatment in 605 Patients With Metastatic Colorectal Cancer: Results of a Randomized Phase III Study ...

This study identified six economic evaluations, which all claimed that TPMT testing for patients prescribed thiopurine drugs was a cost-effective use of healthcare resources. In the majority of cases, ...