PK analysis confirmed the delayed-release, terminal ileum-targeted and colon-targeted profile of PALI-2108. Plasma and tissue PK demonstrated that therapeutically relevant concentrations (above ...

Pharmacokinetics: PK analysis confirmed the delayed-release, terminal ileum-targeted and colon-targeted profile of PALI-2108. Plasma and tissue PK demonstrated that therapeutically relevant ...

terminal ileum and colon-targeted phosphodiesterase-4 B/D (PDE4 B/D) inhibitor being developed for fibrostenotic Crohn's disease (FSCD) and moderate to severe ulcerative colitis (UC). Additionally, ...

PK analysis confirmed the delayed-release, terminal ileum-targeted and colon-targeted profile of PALI-2108. Plasma and tissue PK demonstrated that therapeutically relevant concentrations (above ...

An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across epidemiologic stages 1 ...

Spatial transcriptomics analysis of colon tumours showed a strong coexpression of ALOX5/ALOX5AP known to encode pro-inflammatory leucotrienes in high versus low LTB4 producing CRC tumour samples and ...