"We found that TYK2 adds phosphate groups to tau at a particular location on the protein identified as Tyrosine 29," Kim said. "This modification stabilizes tau levels in human cells and mouse ...

In a study published in the Journal of the American Chemical Society, scientists explore how a brain protein called tau changes its behavior when a small chemical group called a phosphate attaches ...

A new study has somewhat redeemed the tau protein, which up to now has been associated with the development of Alzheimer’s disease. Turns out, the protein has a ‘good guy’ role, helping to ...

A harmful form of the tau protein, which builds up in Alzheimer's disease and similar brain disorders, can directly damage blood vessels in the brain, according to a new study by researchers at ...

New research shows newborns have high levels of tau protein – linked to Alzheimer’s – without harmful effects, offering clues for future treatments.

It does the seeding, causing normal tau protein to misfold and join the fibrils." Using cryo-EM, the team examined the structure of the synthetic fibrils.

Feb 20, 2022 3:52 pm · Updated Feb 21, 2022 11:12 am ...

Novo Holdings led Asceneuron’s $100 million Series C financing. The Merck Serono spinout’s lead program is an oral small molecule designed to prevent aggregation of tau protein in ...

Preventing Tyr29 phosphorylation attenuates tau pathology, but TYK2 expression aggravates pathology in P301S mice. Credit: Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01777-2 ...