Not the Same. In amyloid-negative people (left) few tangles accumulate over a decade. In amyloid-positives (right), tangles grow faster in women (red) than men (blue). [Courtesy of Gillian Coughlan, ...

Two new PET radiotracers have outperformed the only current Food and Drug Administration (FDA) approved radiotracer for detecting tau tangles in the brain, a hallmark of Alzheimer's disease.

Even as this blood-PET work advances, uncertainty around which tau PET tracers are best is still dogging validation efforts. Ratios of phosphorylated tau species in the plasma predict disease stage ...

And while tau-PET remains a reliable and accurate predictor of tau burden in the brain, the test’s utility is limited by availability, low resolution, high cost, labor and sensitivity.

Tau silencing gene therapy VY1706 robustly reduced tau mRNA levels, with broad distribution, and was well-tolerated in NHP study; IND filing ...

individuals with early-stage tau pathology -- which is difficult to detect via tau PET imaging -- have the best chances to benefit from immunotherapy," he continued. "Because of that, our research ...

"When we look at changes over time, we see that women have faster rates of tau accumulation than men in areas of the brain ...

Voyager Therapeutics (VYGR) announced positive topline data from the Company’s single ascending dose, SAD, trial of VY7523, an investigational ...

A new study from Mass General Brigham researchers has found faster accumulation of tau-a key indicator of Alzheimer's disease-in the brains of women over the age of 70 who took menopausal hormone ...

Interim results from three trials exploring the use of Alpha DaRT® in treating pancreatic cancer showing high disease control rate, impressive overall survival in sub-group analyses, and positive safe ...