IEEE

Multi-Scale Graph-Based Cross-Attention Transformer for Whole Slide Image Classification

Abstract: As Whole Slide Images(WSI) are characterized by their extremely high resolution and lack of pixel-level annotation, Multiple Instance Learning(MIL) has become an effective tool for ...
Frontiers

ZC3H18 regulates alternative splicing and related genes in cervical cancer

Introduction: Alternative splicing (AS) and RNA-binding proteins (RBPs) have been implicated in various diseases. However, a comprehensive understanding of their role in RNA metabolism, progression, ...
C&EN

Distribution and Relative Size of Protein Binding Domains Cooperatively Influence Phase Separation of Protein-RNA Mixtures

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
IEEE

Counterfactual Bidirectional Co-Attention Transformer for Integrative Histology-Genomic Cancer Risk Stratification

Abstract: Applying deep learning to predict patient prognostic survival outcomes using histological whole-slide images (WSIs) and genomic data is challenging due to the morphological and ...
BioPharma Dive

Secretive startup Treeline unveils first clinical candidates, $200M in new funding

For the past four years or so, veteran drug hunters Josh Bilenker and Jeff Engelman have kept tightly under wraps the details of their latest project, a biotechnology startup called Treeline ...
BioSpace

Wave Crashes Despite Successful RNA Editing in AATD Study

Wave’s RNA editor resulted in protein levels that were “exceedingly close” to what investors were expecting, but nevertheless fell short of that bar, according to analysts at Truist Securities. Wave ...
Johns Hopkins Medicine

In Extensive Sequencing Study, Scientists Find Few Links Between Cancer and Microbiome

New study: Scientists say a study that sequenced human cancers found far less microbial DNA sequences than earlier studies reported in the same #cancer tissue samples. › About a dozen studies in the ...
FierceBiotech

UPDATE: Analyst questions impact of FDA's rare disease pathway proposal

The FDA has outlined a new review process for drugs and biologics designed to treat ultrarare genetic diseases that would allow a single-arm trial, plus other supportive data, to serve as pivotal ...
GitHub

RNAGenesis: A Generalist Foundation Model for Functional RNA Therapeutics

RNAGenesis is a compact yet powerful RNA foundation model that unifies sequence understanding, de novo RNA design, and 3D structure prediction through a latent diffusion framework. Introduces ...
eLife

Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables controllable self-amplifying RNA expression with reduced immunotoxicity

In this manuscript, Lim and collaborators present an important system for developing self-amplifying RNA with convincing evidence that it does not provoke a strong host inflammatory response in ...
GitHub

BioMCP: Biomedical Model Context Protocol

BioMCP is an open source (MIT License) toolkit that empowers AI assistants and agents with specialized biomedical knowledge. Built following the Model Context Protocol (MCP), it connects AI systems to ...