The systemic lupus erythematosus-associated NCF1 90H allele synergizes with viral infection to cause mouse lupus but also limits virus spread The induction of autoimmune symptoms may require both ...

Gazyva has also been filed for the lupus nephritis indication in Europe, said Roche, which is also expecting a readout from the phase 3 ALLEGORY trial in a broader SLE population later in 2025 and ...

GSK estimates that around 60% of the 300,000-plus severe SLE patients in the US suffer from lupus nephritis each year, and a quarter of those develop end-stage renal disease.

Results Identified Studies The TPMT search strategy identified 253 titles and abstracts of which 223 remained following de-duplication. Of these, nine full papers were retrieved for further ...

Objective Combination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are ...