This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila ...

Braz J Med Biol Res, January 2009, Volume 42(1) 94-104. Synaptic vesicle pool size, release probability and synaptic depression are sensitive to Ca 2+ buffering capacity in the developing rat calyx of ...

SNAP-25 is integral to synaptic vesicle fusion, a process that is disrupted in several neurological conditions, including neurodegenerative diseases like Alzheimer’s and Parkinson’s. The peptide’s ...

Scientists at deCODE genetics, a subsidiary of AMGEN, have discovered rare sequence variants, predicted to cause a loss of function of ITSN1, that are associated with a high risk of Parkinson ...

But how do brain cells send messages? The first step in this messaging process is the action potential, or a wave of electricity triggered in the nerve cell, or neuron.The neurons found in the ...

Upon exocytosis triggering, synaptic vesicles at the active zone gain transient tethers, possibly corresponding to super‐priming. In the second phase, the number of inter‐vesicular connections ...

In addition, the lipids can help to make the protein that allows for the transfer of information between neurons. This process is called synaptic vesicle exocytosis. The fatty acids and proteins in ...

Vesicle recycling is a vital process for the release of neurotransmitters across the synapse since synaptic vesicles must fuse with the presynaptic terminal membrane, in a process called exocytosis.

Vesicle recycling is a vital process for the release of neurotransmitters across the synapse since synaptic vesicles must fuse with the presynaptic terminal membrane, in a process called exocytosis.

Introduction. Vesicle exocytosis releases neurotransmitters and hormones to mediate important functions, such as synaptic transmission, stress responses, and immune responses (Wu et al., 2014; Chang ...

Synaptic Menagerie. Tau contacts all the synaptic vesicle proteins shown, except synaptobrevin, reinforcing the idea that it helps regulate exocytosis. [Courtesy of Tracy et al., Cell.] Most previous ...