This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila ...

The synaptic ribbon is an electron-dense structure found in hair cells and photoreceptors. The ribbon is surrounded by neurotransmitter-filled vesicles and considered to play a role in vesicle release ...

The synaptic vesicle, a cellular compartment tens to hundreds of nanometers in size, is a main player in the process of exocytosis for neuronal communication. Understanding the regulatory mechanism of ...

Focusing on a broadly-conserved 9-nucleotide exon in the synaptic vesicle gene unc-13, we find that it is completely skipped in olfactory neurons, but completely included in motor neurons. This ...

A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis. ... ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific ...

Reference: Gallimore AR, Hepburn I, Georgiev SV, O. Rizzoli S, De Schutter E. Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle. Sci Adv.

Reference: Gallimore AR, Hepburn I, Georgiev SV, O. Rizzoli S, De Schutter E. Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle. Sci Adv.