This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila ...

For example, investigators have demonstrated that neurotransmitter release is intricately controlled by Ca2+ influx, with a supralinear relationship emphasising the sensitivity of synaptic vesicle ...

Reference: Gallimore AR, Hepburn I, Georgiev SV, O. Rizzoli S, De Schutter E. Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle. Sci Adv.

Reference: Gallimore AR, Hepburn I, Georgiev SV, O. Rizzoli S, De Schutter E. Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle. Sci Adv.

Following synaptic vesicle exocytosis, synaptotagmin 1 recruits a lipid signalling pathway within the presynaptic plasma membrane that drives local dynamin recruitment and membrane retrieval by ...

The reconstructed vesicle cycle model provides critical insights into synaptic transmission, advancing neuroscience and potential therapeutic applications.

Summary: A new computational model has mapped the brain’s vesicle cycle in unprecedented detail, providing fresh insight into how nerve cells communicate.Researchers collaborated to simulate how ...

Focusing on a broadly-conserved 9-nucleotide exon in the synaptic vesicle gene unc-13, we find that it is completely skipped in olfactory neurons, but completely included in motor neurons. This ...

A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis. ... ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific ...

We thank the reviewer for raising this question. In the revised manuscript, we examined the protein levels of synaptic proteins after treatment with γ-secretase inhibitors and found that the levels of ...