Pfizer and BioNTech licensed an ionizable lipid called ALC-0315 from Acuitas. Those ionizable lipids, which are remarkably similar in structure, were discovered while the firms were optimizing ...

For small-molecule drug development, the initial lead structure may be derived from modifications of the natural bioactive lipid (for example, using a steroid core, conformationally restricting a ...

Despite the ample structural diversity, structure/activity relationships studies reveal common features. Even when they include different hydrophilic moieties (oxyethylene chains, free hydroxyl, etc.) ...

We report on the aggregation and dynamic behavior of excipients in type I and surfactant-free lipid formulations containing water-soluble cosolvents. Specifically we have investigated the internal ...

Breast cancer is the most common cancer in women in the United States, except for skin cancers. It accounts for about 30% (or 1 in 3) of all new female cancers each year. The American Cancer Society's ...

Myocarditis is an inflammatory disease of the heart that may occur because of infections, immune system activation, or exposure to drugs. The diagnosis of myocarditis has changed due to the ...

Palm Bay Fire Rescue crews responded to a residential structure fire on Titan Road in the southeast part of the city, just before 1 p.m. on Thursday, May 15. Palm Bay Fire Rescue officials suspect ...

Despite the controversies surrounding his steroid use and the subsequent lawsuit, Johnson continues to operate his business. Ancestral Supplements, along with its sister brand The Fittest Ever ...

Injected corticosteroids can reduce the inflammation. But you must be careful because repeated steroid use can cause the tendon to weaken or even rupture. Carpal tunnel syndrome. This condition ...

Small, lipophilic, and uncharged molecules pass more easily, and formulations often include mild penetration enhancers, such as alcohols or glycols, to temporarily loosen the lipid structure and ...

The structure of the premises is assessed to be unstable. Image from SCDF A person from the affected premises was assessed by an SCDF paramedic for a minor cut on his arm. The person declined to ...

The impact of lipid core burden index (LCBI) after percutaneous coronary intervention (PCI) in the stented segment assessed by intracoronary near-infrared spectroscopy on the outcomes remains unclear.