In the present study, when the aldosterone inhibitor spironolactone was found to be effective in increasing sodium and water excretion, it also increased the average twenty-four-hour potassium loss.

This study aimed to refine understanding of the antifibrotic action of spironolactone. Methods In this substudy (n=290) to the Heart ‘Omics’ in Ageing Study trial, patients were randomised to usual ...

Spironolactone – sometimes called “spiro” for short – has been a miracle drug for many suffering from acne, PCOS, and hair ...

New findings from CLEAR SYNERGY (OASIS 9) comparing spironolactone vs. placebo in patients with myocardial infarction (MI) found that the mineralocorticoid receptor antagonist did not reduce the ...

The logical target of research was aldosterone antagonism. The effectiveness of spironolactone demonstrated in RALES is impressive, although the study's results should be interpreted with caution.

Similar increases in plasma aldosterone concentrations were also ... was reported in one patient in the spironolactone treatment group. Specifically, no reports of impotence or gynecomastia ...

Oversecretion of aldosterone is a consistent finding in the syndrome of malignant hypertension. Infusion of angiotensin has been consistently shown to induce an increased secretion of aldosterone by ...

which involves an increase in the secretion of aldosterone, because of its function in governing volume and electrolyte homeostasis in the body. Mineralocorticoid receptor (MR) antagonists, mainly ...

known to influence aldosterone production. In a 109 RHTN population ... reported obvious improvement of AHI and BP after an add-on therapy of eplerenone or spironolactone in OSA patients with RHTN.

APAs indicates aldosterone-producing adenomas ... of newer mineralocorticoid receptor antagonists that lack the sex-steroid–related side effects of spironolactone and of highly specific CYP11B2 ...

Key Takeaways Spironolactone is effective for both premenopausal and postmenopausal women Finasteride is primarily used for postmenopausal women Both medications lower DHT levels and reduce hair loss ...