Structure activity relationship studies reveal that minimal modifications to the dimethylaniline moiety of S656 improve its cyclin K MGD function over CDK inhibition by promoting DDB1 engagement. This ...

Successful research in targeted protein degradation depends not only on measurements at high sensitivity, speed and precision but also on having the flexibility to accommodate emerging assays.

Multi-level molecular modeling reveals how PROTAC-induced protein structural dynamics of degradation machinery complexes promote ubiquitination processes.

Craig Ester, left, is Ira Aldridge and Marina DeYoe-Pedraza is Betty Lovell in Swine Palace's production of 'Red Velvet,' which continues its run at LSU's Shaver Theatre on campus. STAFF PHOTO BY ...

BACKGROUND: Ang-II (angiotensin II) impairs the function of the antihypertensive enzyme ACE2 (angiotensin-converting enzyme 2) by promoting its internalization, ubiquitination, and degradation, thus ...

Pentacyclic triterpenoids (PTs) are a class of plant metabolites with a wide range of pharmacological activities, including strong antitumor potential against skin malignancies. By acting on multiple ...

SKP2 inhibitor treatment resulted in increased survival of YAP5SA mice, marked by frequent detection of P21 in cardiomyocytes compared with vehicle-treated YAP5SA controls (Figure S10C and S10D).

This new article publication from Acta Pharmaceutica Sinica B, discusses how molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH. Cancer stem cells ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.

Prostate cancer (PCa) represents a highly heterogeneous disease that requires tools to assess oncologic risk and guide patient management and treatment planning. Current models are based on various ...