Steep declines in the expression of glucose-transporter Glut1. Cells with Skp2 produced more Glut1 when induced by epidermal growth factor signaling. Akt activates Glut1.

Steep declines in the expression of glucose-transporter Glut1. Cells with Skp2 produced more Glut1 when induced by epidermal growth factor signaling. Akt activates Glut1.

Article Reference: Shi-Bing Zhang, Ming Hong and Xiao-Yang Sun et al. Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2. Acta Materia Medica. Vol. 1 (3 ...

The ubiquitin ligase SKP2, which is part of the SKP1–CUL1–F-box (SCF) complex, has been implicated in tumorigenesis owing to its capacity to degrade the tumour suppressor p27, a cyclin ...

Background: p45 S phase kinase-associated protein-2 (p45 skp2), a member of the F-box family of proteins, is an important component of the Skp1-Cullin-F-box protein (SCF) ubiquitin-ligase complex (SCF ...

Skp2 is involved in promoting cell cycle regulation, cell proliferation, cell growth and the formation of tumours, and it is over expressed in a variety of human cancers, according to lead author ...

The 3′UTR of SKP2, which contains a putative target region for miR-186, was PCR amplified from genomic DNA. The SKP2 3′UTR mutant construct was generated by overlap extension PCR.

Background: p45 S phase kinase-associated protein-2 (p45 skp2), a member of the F-box family of proteins, is an important component of the Skp1-Cullin-F-box protein (SCF) ubiquitin-ligase complex (SCF ...