Defining skeletal editing is both easy and hard. For the most part, Levin says, chemists agree that the skeletal part refers to the core structure of a molecule, especially the types of rings it ...

Sarpong and his team synthesized a morphine derivative in which the oxygen atom in one of its central rings has been replaced with a carbon (Proc. Nat. Acad. Sci. U.S.A. 2025, DOI: 10.1073/pnas ...