This study finds these bacteria as the first example of an organism using ADP-ribose modification of DNA as a mechanism for regulating gene transcription and cellular replication. The ...

such as gene transcription and DNA replication. Some of these structures have also been linked to diseases like cancer. Mapping these regions will allow researchers to study these structures ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease ...

Each strand serves two primary purposes: acting as a template during DNA replication and providing instructions for protein synthesis in a process called transcription. Replication and ...

Each strand serves two primary purposes: acting as a template during DNA replication and providing instructions for protein synthesis in a process called transcription. Replication and ...

Here, we use 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replication collisions to genome instability. After deconvoluting robust SV signatures in three ...

Based on experimentally determined average inter-origin distances of ~100 kb, DNA replication initiates from ... genomic features independently specify the origins of replication and promoters of ...

However, whether transcription plays a greater role in the organization of chromatin following DNA replication remains unclear. Here we analysed protein re-association with newly replicated DNA upon ...

Replication of the genome must be coordinated with gene transcription and cellular metabolism ... checkpoint kinase plays a major role in cellular responses to DNA replication stress. Cell cycle ...

he wondered. In a study published Tuesday in the journal Cell Reports, Dr. Esteller and his team recruited 32 pairs of look-alikes from Mr. Brunelle’s photographs to take DNA tests and complete ...

In contrast, SIRT2 silencing inhibited HBV transcription and replication. In addition, we found a positive correlation between SIRT2 expression and HBV RNAs synthesis as well as HBV covalently closed ...

This genetic material is needed to regulate and inform cell function through the creation of RNA by transcription ... than mitosis and involves DNA (nucleoid) replication, chromosomal segregation ...