Mutations in EGLN1, the gene encoding for hypoxia-inducible factor (HIF) prolyl-4-hydroxylase 2 (PHD2), cause erythrocytosis and in rare cases the development of neuroendocrine tumors. In the presence ...

This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila ...

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Cells communicate by transporting vesicles and organelles, which is essential for maintaining cellular homeostasis. However, dysregulated vesicle transfer between cells can contribute to several ...

development of dna-based vaccines against flaviviruses: membrane-envelope proteins co-expressed as lamp fused antigens The genome of the yellow fever virus, the prototype of the flavivirus family, is ...

To further expand the knowledge concerning the NK inhibitory signal transduction via the NKG2A/CD94 receptor, we constructed the complete structure of the membrane-embedded NKG2A/CD94 receptor with ...