From Prescott to La Crosse on Scenic Wisconsin Highway 35 The Great River Road in Wisconsin starts where the St. Croix and Mississippi Rivers meet. The town of Prescott is located at this convergence.

Officially called the Great River Road National Scenic Byway, this series of state and local highways and roads follows the course of the Mississippi River for 3,000 miles, through 10 states.

GENOA — Travelers on Wisconsin’s Great River Road will soon be able to learn about the Mississippi River and its people with the completion of a long-delayed federal project.

Illinois/Iowa (KWQC) - Great River Road has been selected as the Best Scenic Drive in America in the 2025 USA Today Ten Best Readers’ Choice Awards. Travelers nominated 20 routes, including ...