Selectivity for closely related isoforms of protein kinases is a major challenge in the design of drugs and chemical probes. Covalent targeting of unique cysteines is a potential strategy to achieve ...

Synopsis Cell culture is considered a microenvironment with high oxygen. Here, terminally-differentiated cells are shown to be deprived of pericellular oxygen in standard culture systems. mandating ...

Russian Culture Minister Olga Lyubimova arrived in North Korea on Saturday with a 125-strong delegation of performers and praised cultural cooperation between Moscow and Pyongyang for achieving ...

METHODS AND FINDINGS By employing established in vitro culture methods, we demonstrate a significantly higher capacity for titan cell formation in Cryptococcus spp. Cells grown in complete NB medium ...

In doing so, this novel culture helps reduce water and energy use in production while maintaining the high quality of the final products to meet consumer expectations.