Semaglutide melts fat—but may quietly strip away your strength Date: July 15, 2025 Source: The Endocrine Society Summary: Semaglutide, a popular anti-obesity drug, may come with a hidden cost ...

Tirzepatide outperformed semaglutide in simultaneously achieving four key therapeutic targets for type 2 diabetes.

Tirzepatide was superior to semaglutide in achieving standard and intensive cardiometabolic targets among patients with type 2 diabetes.

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Key Takeaways GLP-1 RAs, semaglutide and tirzepatide, significantly lower dementia, stroke, and all-cause mortality risks in T2D and obesity patients compared to other antidiabetic drugs.

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Among patients receiving semaglutide for obesity management, the risk for muscle loss may be higher in older adults and women, and a high protein intake can mitigate this risk.

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People who took semaglutide over a slower, more flexible schedule were significantly less likely to experience nausea and to discontinue use.