Update: A motorcyclist died from his injuries after a crash on Route 22 in Easton that closed part of the highway for hours Saturday afternoon.

One person is dead after a Wednesday afternoon crash on U.S. Route 22 in Lebanon County. The crash happened eastbound near ...

A man was killed in a crash on Route 22 in Lebanon County on Wednesday evening, according to Pennsylvania State Police. The ...

A four-vehicle accident involving an overturned box truck carrying food blocked lanes on Route 22 east Monday afternoon.

Schuylkill Haven resident Cory Rhoad died after crashing into a Honda driven by a 67-year-old man from Palmyra in East ...

PennDOT announced today that a lane restriction will begin today along Route 68/East Jefferson Street for the Karns Crossing ...

A 27-year-old man originally from Wallington, New Jersey, was killed when his car flew off Route 22 at over 100 mph and struck multiple trees, Pennsylvania State Police said. David Puchala, of ...

A man was injured when he crashed his SUV Monday morning during a police pursuit along Route 22 in South Whitehall, state police said. Pennsylvania State Police in Fogelsville said troopers were ...

Crews responded to Allentown Boulevard/Route 22 and Coon Creek Road in East Hanover Township around 9:45 a.m. The crash blocked traffic and caused slowdowns in the area until the scene cleared.

DAUPHIN COUNTY, Pa. — Update (11:30 a.m.): The victim of the crash has been identified as 24-year-old Makayla Creeley of Halifax, who was the passenger in the car, according to Pa. State Police.

Route 22 welcomed its first drivers in September of 1954, when then-Pa. Gov. John Fine cut the ribbon at the Airport Road interchange that symbolically opened the new highway.