The retinoid X receptor (RXR), a member of the nuclear-receptor superfamily, is a common binding partner for a subgroup of other nuclear receptors.

OBJECTIVE: To investigate whether retinoid X receptor agonists act as insulin sensitizers and compare their effects with that of thiazolidinedione BRL 49653 in obese Zucker rats. DESIGN: In two ...

The present study determined the influence of a retinoid X receptor agonist bexarotene on angiogenesis and metastasis in solid tumours. In the experimental lung metastasis xenograft models ...

A regulator of gene expression, retinoid X receptor (RXR), can boost scavenging cells in their mission to clear the brain of dead cells and debris after a stroke, thus limiting inflammation and ...

Cooperative antitumor activity between the retinoid X receptor (RXR)-selective agonist bexarotene and EGFR-tyrosine kinase inhibitors in preclinical models of NSCLC. JCO 24 , 17073-17073 (2006). DOI: ...

The action of a nuclear receptor (NR) is determined by the balance between corepressors and coactivators. These receptors (bound to DNA as heterodimers with the retinoid X receptor or as ...

7157 Background: Gefitinib (Iressa) is an orally active epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) approved for the treatment of advanced non-small cell lung cancer (NSCLC).

Retinoids and retinoid analogues exert their activities by interacting with nuclear receptors (RARs [retinoic acid receptors] or RXRs [retinoic X receptors]) on cells and by activating genes that ...

Lower levels of retinoid receptor expression correlated to hand eczema, according to a poster presented at American Academy of Dermatology virtual meeting. In a case-control study, 30 patients ...

Barnes, S. A., et al. (2025) Non-ionotropic signaling through the NMDA receptor GluN2B carboxy-terminal domain drives ...