Figure 6: Mechanism of Anti-EGFR resistance in head and neck cancer by activation of TLR4-MyD88 signaling. EGFR inhibition by cetuximab prevents Src activation, thus preventing MyD88 degradation ...

Home » SOS1 inhibitor HM-99462 demonstrates synergy with RTK-KRAS-MAPK signaling inhibitors. X. Upgrade your daily dose of biopharma and medtech news. Subscribe to BioWorld™ news services. See ...

Receptor tyrosine kinases (RTKs) are a large group of integral membrane signaling molecules. Mutations in the RTK anaplastic lymphoma kinase (Alk) protein have been linked with non-Hodgkin lymphoma, ...