Though RTK fusion proteins have long been a target of anti-cancer drugs, these drugs have generally worked by blocking the site in the fusion protein responsible for producing pro-cancer signals.

Instead, TNBCs exhibit broad, rather than selective, hyper-activation of RTK signaling, with several proto-oncogenic RTKs hyper-activated in the same tumor. Recent discoveries have revealed that the ...

The signaling pathway was monitored by cignal 45-pathway reporter array. RTK-RTK interactions were determined by co-precipitation and Western blot. Study findings ...

Deregulation of Receptor Tyrosine Kinase (RTK) signaling underlies a large fraction of human cancers. These genetic perturbations lead to a variety of cell autonomous and non-cell autonomous effects ...

Papyrus's lead therapeutic is a modified, recombinant version of Opioid Binding Protein/Cell Adhesion Molecule-like (OPCML), which is an extra-cellular, upstream regulator of RTK activity.

The researchers, including Mohamed Soliman of Cairo University, considered the function of Receptor Tyrosine Kinase (RTK) to try to understand why it is a necessary mediator in this process. Upon ...

The Rice-Princeton team showed the “live reporter” system could be used with a microscope to produce a video record of signaling network activity in living cells. Where cells glow and how brightly, ...

In 2015, researchers at UC San Francisco found a structure inside of tumor cells that biologists had never seen before. Even more surprising, a closer examination of the structure revealed that it ...