The Food and Drug Administration (FDA) has granted Fast Track designation to MC-1 for the treatment or prevention of seizures associated with pyridox (am)ine 5′-phosphate oxidase (PNPO) deficiency.

Pyridoxal 5-phosphate (PLP) is an essential coenzyme involved in diverse amino acid transformations. The discovery that Ind4 catalyzes the PLP-dependent oxidation of an unactivated carbon of L ...