This important study presents a compelling theoretical framework for understanding phase separation of membrane-bound proteins, with a focus on the organization of tight junction components. By ...

This fundamental study combines in vitro reconstitution experiments and molecular dynamics simulations to elucidate how membrane lipids are transported from the outer to the inner membrane of ...

TMBIM5 is a substrate and inhibitor of the m‐AAA protease AFG3L2. Mitochondrial hyperpolarization ... The ultracentrifugation tube containing TMBIM5‐liposomes in discontinuous histodenz gradient after ...

The term “protease inhibitor” refers to a class of medications rather than to a single medication. Specifically, they are antiviral drugs. But unlike the many, more common antiviral drugs that ...

Three weeks after Roche’s Genentech unit walked away from an SHP2 inhibitor pact, Relay Therapeutics has confirmed that it won’t be pushing ahead with the asset solo. Genentech initially paid ...

Simnotrelvir is an oral 3-chymotrypsin–like protease inhibitor that has been found to have in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential ...

(2) Lopinavir made sense to try because it wasn't really a repurposed drug; it's an inhibitor of HIV protease and one of the approved AIDS drugs. Covid also has a protease enzyme, albeit one with a ...

Please provide your email address to receive an email when new articles are posted on . FDA granted fast track designation to Palisade Bio’s broad-spectrum serine protease inhibitor, LB1148, for ...

Glecaprevir, a protease inhibitor discovered by Enanta, is part of one of the leading treatment regimens for curing chronic HCV infection and is sold by AbbVie in numerous countries under the ...

The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-risk, unvaccinated patients infected with the B.1.617.2 (delta) variant of severe acute respiratory syndrome ...