Half the cells were lysed in 20 mM Tris-HCl pH 7.4, 150 mM NaCl, 0.2% NP-40 containing protease inhibitors and centrifuged. Lysates were analyzed for caspase-8 (MBL), caspase-9, caspase-3 ...

These proteases typically lie dormant in the healthy ... Initiator caspases (such as caspase 8 and caspase 9) activate the effector caspases and have long prodomains that allow them to interact ...

Caspase family of cysteinyl-proteases plays the key role in the initiation and execution ... Some caspases have long prodomains containing special motif such as DED (caspase-8 and -10), and caspase ...

Total protein was extracted using ice-cold RIPA lysis buffer (Millipore Sigma, Cat #R0278) supplemented with a 1X protease inhibitor cocktail ... primary antibodies were used as follows: Rabbit ...

A new blood test could help doctors detect pancreatic cancer earlier, potentially improving survival rates for one of the ...

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Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In 2020–2021, a “mysterious illness” struck ...

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Institute for Drug Discovery, Leipzig University Medical School, Brüderstraße 34, Leipzig 04103, Germany Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Leninskie Gory ...