This finding reveals how striatal spiny projection neurons operate on a "use it or lose it" basis, weakening synapses that were not actively involved in controlling behavior, Surmeier said.

A new study reveals that neurons in the brainstem respond very differently to acute versus chronic pain, potentially ...

More information: Patricia Bonnavion et al, Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs, Nature Neuroscience (2024). DOI ...

Study uncovers how gradual CAG repeat expansion in neurons drives the onset of Huntington’s disease, offering new insights for potential therapeutic interventions. Study: Long somatic DNA-repeat ...