Currently dopamine replacement medications, like levodopa and dopamine agonists, are the primary treatment for Parkinson's ...

Gerstmann-Strässler-Scheinker syndrome (GSS) is a rare, inherited brain disorder. It can affect cognitive function, coordination, and movement symptoms.

Weidentified an uncharacterized Arabidopsis thaliana prion-like protein we named FLOE1, which phase separates upon hydration and allows the embryo to sense water stress. We demonstrate that ...

Misfolded, prion-like proteins drive the progression of tauopathies (resulting in neurodegenerative diseases) characterized by the abnormal accumulation of misfolded tau protein in the brain.

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and stacks ...

First synthetic 'mini prion' shows how protein misfolding multiplies Model enables study of fundamental interactions underlying neurodegenerative disease Date: April 28, 2025 Source: Northwestern ...

ARTICLES Characterization of TcSTI-1, a homologue of stress-induced protein-1, in Trypanosoma cruzi Juliana C Schmidt II, III; Maurilio J Soares II; Samuel Goldenberg I, II; Daniela Parada Pavoni II; ...

How to silence Next, the team had to decide how to silence the gene. They originally used part of a methyltransferase molecule – DNMT3A – that can add methyl groups to DNA. The necessary conformation ...

Collaborating with a genome-editing lab, they have developed a tool that can turn off expression of the prion protein in a mouse’s brain and that might work for other disease-related proteins ...

A study from Bochum describes a mammal-specific domain of the prion protein and offers new approaches for research into neurodegenerative diseases. At first, they cause memory deficits and ...