Prion diseases are characterized by abnormal folding of the host’s naturally-occurring prion protein, leading to rapid neurodegeneration. They can be genetic, sporadic—without known cause—or acquired, ...

Explorations of toxic protein species via genetic disease ... If so, PrP C contributes to neurotoxicity in prion disease but by uncertain mechnisms.

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. The work demonstrates that ...

Some rare forms of dementia, including Creutzfeldt-Jakob disease (CJD) are caused by a type of protein called a prion. In these conditions, the prions misfold into a toxic form and then spread ...

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for immunotherapy. In the March 6 Nature, Anthony R. White ...

Jan. 6, 2025 — Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now ...

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. There is currently no cure ...

Prion diseases come about when misfolding of prion proteins occurs in the nervous system. They all progress until the infected person dies. Prior research has shown that progression occurs due to ...

In in vitro cell culture models of AD, curcumin-encapsulated biodegradable PLGA nanoparticles have been found to reduce ...