They found that the prion-domain of Sup35 acts like a stress sensor that triggers the formation of protective protein droplets and gels when cells are exposed to harsh conditions.

The bright side of an infectious protein Stress sensors promote yeast cell survival Date: January 9, 2018 Source: Max-Planck-Gesellschaft Summary: Prions are self-propagating protein aggregates ...

Scientists have detected abnormal prion protein in the skin of several people who died from Creutzfeldt-Jakob disease (CJD). The scientists also exposed healthy mice to skin extracts from two CJD ...

The prion protein forms functional condensates that are enriched at cell-cell interfaces. However, long exposure to copper ions/hydrogen peroxide that result in oxidative stress, triggers a liquid ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The "mini prion" folds and stacks ...

In the study, the team discovered that the prion protein plays a key role in the biology of glioblastoma. "The treatment of ...

Non-infectious form of prion protein could cause brain degeneration. You have full access to this article via your institution. Non-infectious prion proteins found in the brain may contribute to ...

Prion study identifies druggable therapeutic targets that could, ... and stimulation of specific mitogen-activated protein kinases, ... (an enzyme that typically responds to stress, ...

Based on experiments with yeast, different cell lines, a newly created strain of transgenic mice, and previous work (Ma & Lindquist, 2001), the authors propose the following mechanism for how sporadic ...

They found that the prion-domain of Sup35 acts like a stress sensor that triggers the formation of protective protein droplets and gels when cells are exposed to harsh conditions.

Tech & Science First synthetic ‘mini prion’ shows how protein misfolding multiplies. Scientists plan to explore potential applications, including the development of new diagnostic and ...