First synthetic 'mini prion' shows how protein misfolding multiplies Model enables study of fundamental interactions underlying neurodegenerative disease Date: April 30, 2025 Source: Northwestern ...

Targeting cellular structures called nuclear speckles could be a completely new approach for treating ...

A groundbreaking study reveals that reshaping nuclear speckles — tiny structures inside cell nuclei that regulate protein maintenance — could be a novel way to treat proteinopathies like Alzheimer’s, ...

The first synthetic fragment of tau protein has been created, revealing more about the diagnosis and treatment of neurodegenerative diseases. Researchers at Northwestern University (IL, USA) and the ...

Now that this synthetic prion model is available, the researches want to learn more about prion-like proteins and find ways to use them. For example, they may be applicable in the creation of ...

A fluorescence-based technique that identified misfolded prion proteins with single-molecule sensitivity and determined the role of metal ions in misfolding. The researchers used this technique to ...

Interestingly, the disordered region, the so-called N-terminal domain of the prion protein, has developed differently in mammals than in amphibians. This suggests a new function for mammalian PrP ...

The group then studied the interaction of prion with the CD44 protein, a well-known cancer stem cell marker involved in the collective invasion of breast and colon cancers.

Tech & Science First synthetic ‘mini prion’ shows how protein misfolding multiplies By Dr. Tim Sandle Published May 28, 2025 ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and ...