what is the computational implication of having multiple spines connecting to the same presynaptic bouton? What could be the advantage of having two distinct spines, which, on all accounts ...

It may involve presynaptic and postsynaptic mechanisms. Complex signalling cascades link the induction of LTD to its expression. The cascades involve Ca 2+ sensors, protein–protein interactions ...

Using time-lapse imaging, Weinhard et al., recently reported that, rather than removing the whole synaptic structure, microglia prune presynaptic structures through a selective partial phagocytic ...

The biological fates of the key initiator of Alzheimer’s disease (AD), the amyloid precursor protein (APP), and a family of lipoprotein receptors, the low-density lipoprotein (LDL) receptor-related ...

Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan ...