Confinement within the presynaptic bouton is mediated in part by SV protein association with the clathrin-based endocytic machinery to limit diffusional spread of newly exocytosed SV proteins.

A represents a 3D electron microscopy analysis of glial phagocytosis. In the brain, presynaptic bouton (blue) sends information to the postsynaptic spine (yellow). Such synaptic contact is ...