Class B G-protein-coupled receptors (GPCRs) are receptors for peptide hormones that include glucagon, parathyroid hormone, and calcitonin. These receptors are involved in a wide spectrum of ...

Copper and chromium prevented cells from taking up the hormone, but other metals such as zinc, cobalt and manganese did not have such an effect. The results show that metals can potentially “tune” the ...

Investigations suggest that the peptide may contribute to cellular resilience, metabolic regulation, and neurophysiological adaptability, potentially implicating it in integrative research.

H2 relaxin activates the relaxin family peptide receptor-1 (RXFP1), a class A G-protein coupled receptor, by a poorly understood mechanism. The ectodomain of RXFP1 comprises an N-terminal LDLa ...

The 9-amino acid peptide Oxytocin (OT) has a sulfur bridge connecting its two cysteines. Research indicates that the posterior pituitary gland, a small organ near the brain's base, may be responsible ...

Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Science, 2023; 381 (6657): 502 DOI: 10.1126/science.abq3178 ...

The researchers further analyzed the structure of the ribosome arrested by the PepNL nascent peptide. Their findings revealed that the PepNL nascent peptide adopts a stable mini-hairpin ...

Calcemic fraction-A (CF-A) is a biologically active, hypercalcemic and bone resorptive peptide, which was detected in, and isolated from, bovine parathyroid glands [Hamilton et al. (1971) ...

A team led by Katrine T. Schjoldager of the University of Copenhagen has now identified the largest number of O-linked glycosylated peptide hormones yet found (Nat. Commun. 2020, DOI: 10.1038 ...

A research team at the University of Vienna, led by medicinal chemist Markus Muttenthaler, has developed a new class of oral peptide therapeutic leads for treating chronic abdominal pain.

Analysis of metal effects on C‐peptide structure and internalization. ChemBioChem, 2019; DOI: 10.1002/cbic.201900172 ...