One of the key classes of such receptors are so-called G protein-coupled receptors, or ... "That suggests fine-tuned properties that transcend these standard canonical pathways. Now, we have a ...

"G-protein-coupled receptors are ubiquitous in the function of cells in the body and help us to sense light, flavour and odour. They are also responsible for the human body's reactions to chemicals in ...

G protein-coupled receptors (GPCRs), crucial for diverse physiological responses, have traditionally been investigated in their monomeric form. However, some GPCRs can form heteromers, revealing ...

A recent study published in Nature by a research team from the United States and China introduced a new class of engineered G-protein-coupled receptors (GPCRs) called programmable antigen-gated ...

Although G protein-coupled receptors (GPCRs) are crucial to the regulation of most functions in the human body, very little is known about how they work. In a new study, researchers at the Biozentrum ...

Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Compuscript Ltd. DOI 10.1016/j.apsb.2023.07.020 ...

Understanding what drives progression may help identify proteins and pathways that can be targeted to slow down the disease. Hepatocellular carcinoma (HCC), which accounts for up to 80% of cases of ...

G protein–coupled receptor, class C group 5 member D (GPRC5D), a type C 7-pass transmembrane receptor protein, is expressed on malignant and normal plasma cells at least 500-fold higher in bone marrow ...

MCARH109 is a first-in-class G protein–coupled receptor, class C, group 5, member D (GPRC5D)-targeted chimeric antigen receptor (CAR) T-cell therapy for patients with relapsed/refractory multiple ...