Creatine supplementation may improve cognitive performance and mood, offering insights into its role in muscle-brain ...

G protein-coupled receptors (GPCRs), crucial for diverse physiological responses, have traditionally been investigated in their monomeric form. However, some GPCRs can form heteromers, revealing ...

Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Compuscript Ltd. DOI 10.1016/j.apsb.2023.07.020 ...

A recent study published in Nature by a research team from the United States and China introduced a new class of engineered G-protein-coupled receptors (GPCRs) called programmable antigen-gated ...

19 F NMR revealed several functional activation states of A 2A R when it is coupled to G s and G o G-proteins. When A 2A R is engages with its preferred G s partner, the receptor adapts long-lived ...

Although G protein-coupled receptors (GPCRs) are crucial to the regulation of most functions in the human body, very little is known about how they work. In a new study, researchers at the Biozentrum ...

G protein–coupled receptor, class C group 5 member D (GPRC5D), a type C 7-pass transmembrane receptor protein, is expressed on malignant and normal plasma cells at least 500-fold higher in bone marrow ...

Understanding what drives progression may help identify proteins and pathways that can be targeted to slow down the disease. Hepatocellular carcinoma (HCC), which accounts for up to 80% of cases of ...

MCARH109 is a first-in-class G protein–coupled receptor, class C, group 5, member D (GPRC5D)-targeted chimeric antigen receptor (CAR) T-cell therapy for patients with relapsed/refractory multiple ...