Background Fibrotic interstitial lung diseases (fILDs ... approved management approaches are limited to two therapies that prevent the progression of fibrosis. The drug development pipeline is long ...

About 50%–65% of systemic sclerosis patients show interstitial lung abnormalities on HRCT ... It is important to note that SOX9 has a role in pathophysiology of organ fibrosis. SOX9 is well recognized ...

Endomyocardial fibrosis (EMF) was described as a distinct clinicopathological ... but there is still some controversy regarding the pathophysiology of central cyanosis, ascites and the absence of ...

Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and ...

The genetic disorder cystic fibrosis is unique because it can cause both breathing and digestive problems. Some 40,000 people in the U.S. currently have it, "though this is likely an ...

Patients with progressive pulmonary fibrosis who received nerandomilast showed improved forced vital capacity from baseline ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists ... based on substrate specificity: (1) interstitial collagenases (MMP-1, -8, -13); (2 ...

Burroughs, F.Med.Sci.; Amar P. Dhillon, M.D. It should be emphasized that although fibrosis is a very important component of stage, the two terms are not synonymous; stage is a wider term ...

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The evolution of a disease resulting in functional changes in your body is known as pathophysiology. To understand COPD’s pathophysiology, it’s important to understand the structure of the ...