In these videos, Gideon Hirschfield, PhD, Lily and Terry Horner Chair in Autoimmune Liver Disease at the University of Toronto, discusses the latest advancements in the treatment of biliary diseases.

Despite new market entrants in the form of Gilead's Livdelzi and Ipsen's Iqirvo, US gastroenterologists report nearly half of PBC patients suffer fro ...

Zen types will tell you to accept the itch, to meditate on it, as you might do if you were in pain. These people have no idea what they are talking about. Watching someone scratch makes you itchy; ...

On the itch-scratch cycle. Histamine is an amazing chemical that does many, many, many things in our body and it's part of our immune response. It leads to swelling so the body can come in to heal.

Linerixibat induced a dose-dependent reduction in itch among patients with primary biliary cholangitis-associated pruritus, according to results published in Clinical Gastroenterology and Hepatology.

New data from the ELATIVE® Phase III trial show 70% of patients treated with elafibranor achieved composite endpoint of slowing disease progressio ...

Seeking to rejuvenate itself after recent disappointments, Gilead Sciences Inc. proposes to bolster its liver portfolio by taking over Cymabay Therapeutics Inc. for $32.50 per share in cash, a total ...

GSK plc (LSE/NYSE:GSK) announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for linerixibat, an investigational oral treatment targeting ...

PBC is an orphan progressive chronic disease, caused by an imbalance in bile homeostasis, that leads to cholestasis and associated symptoms including pruritus (intense itch) and liver injury.

Linerixibat works by inhibiting the ileal bile acid transporter (IBAT), reducing mediators of pruritus in circulation. Both the FDA and EMA have granted the drug orphan designation for treating ...

Journalist Annie Lowrey has a rare disease that causes a near-constant itch that doesn't respond to most treatments. She likens the itchiness to a car alarm: "You can't stop thinking about it." ...