The assembly of outer membrane proteins (OMPs) in Gram-negative bacteria is a fundamental process that underpins bacterial viability and resilience. Central to this process is the β-barrel assembly ...

Ikoma, Japan—Gram-negative bacteria pose a significant threat to global health due to their high resistance to antibiotics compared to that of Gram-positive bacteria. Their formidable defensive ...

Gram-negative bacteria pose a significant threat to global health due to their high resistance to antibiotics compared to that of Gram-positive bacteria. Their formidable defensive capabilities stem ...

They derive their energy from differences in the concentration of hydrogen ions across some of these membranes ...

The Tol-Pal complex maintains bacterial outer membrane (OM) stability by regulating lipid homeostasis. (Left) In Gram-negative bacteria, the OM acts as a protective barrier, blocking entry of harmful ...

Membrane proteins are ubiquitous cellular components that are responsible for a wide array of cellular and molecular activities, including drug metabolism, lipid shuttling, and antibiotic resistance.

Proteins designed by artificial intelligence (AI) are being considered for use in treating everything from snakebites to cancer. A Nature Communications paper, out this week, describes how Australian ...

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

(β-ARs) regulate cardiac function during sympathetic nerve stimulation. β-ARs are present in both the cardiac T-tubule (TTM) and outer surface membrane (OSM), but how their location impacts their ...

Ferroptosis, a regulated cell death mechanism, is emerging as a promising target for cancer therapy. The process is mediated by the activity of acyl-CoA synthetase family member 4 (ACSL4) protein.

Blocking calcium entry or the MAPK relay was enough to stop every downstream response. Breathing in the duo drives classic allergy signs in mice, with eosinophils in the lungs, T-helper-2 cells, and ...