Further, the role of the normal prion protein known as PrPc in iron metabolism may provide a target for strategies to maintain iron balance and reduce iron-induced neurotoxicity in patients ...

A new study suggests that the normal form of prion protein helps maintain the insulation that speeds electrical signals along nerve fibers. In its twisted Mr. Hyde form, the prion protein causes ...

In the study, the researchers created a large fragment of the normal prion protein -- a harmless protein found in all mammals examined. They then folded this fragment into the abnormal shape that ...

A team of researchers from Case Western Reserve University School of Medicine have identified a mechanism that can prevent the normal prion protein from changing its molecular shape into the ...

As part of the new study, Prusiner, Legname and their colleagues created a large fragment of a normal prion protein and folded it using lab techniques into an abnormal shape, which they suspected ...

Misfolded, prion-like proteins drive the progression ... which ultimately damage brain health but are difficult to diagnose. When a normal protein encounters the pathological tau fibrils, the ...

A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally, so studying the rare disorders that result can provide insights into other neurodegenerative diseases ...

“Our study demonstrates that misfolding a particular segment of the normal prion protein is sufficient to transform the protein into infectious prions,” said lead researcher Giuseppe Legname ...

Sporadic CJD (sCJD) Unknown, but widely believed to be due to a spontaneous misfolding of the normal prion protein. Affects mainly people over the age of 60. Common symptoms include ataxia and ...

Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and stacks into strands (or fibrils) of misfolded tau proteins, which then ...

Further, the role of the normal prion protein known as PrPc in iron metabolism may provide a target for strategies to maintain iron balance and reduce iron-induced neurotoxicity in patients ...

In the study, the researchers created a large fragment of the normal prion protein -- a harmless protein found in all mammals examined. They then folded this fragment into the abnormal shape that ...