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For example, quinine can inhibit neurons that have been stimulated by sucrose and vice versa. We believe neuromodulation, particularly norepinephrine from the LC, is critical for controlling the ...

A 2025 systematic review and meta-analysis of cold-water immersion, for example, examined the effects of cold-water immersion across 11 studies involving 3,177 participants.

The third study, led by Marc Freeman of Oregon Health Sciences University in Portland, reported that norepinephrine rendered astrocytes more reactive to other neurotransmitters, including dopamine.