This research will provide valuable insights into our understanding of mechanisms of addiction ... with the upregulation of nicotinic acetylcholine receptors (nAChRs), a critical indicator of ...

Second, it summarizes the effects of AME on cardiocerebrovascular diseases and neurological disorders, and its specific pharmacological mechanisms ... were conducted with the human α7 nicotinic ...

The delta opioid receptor (DOP) plays a key role in mood ... However, the precise molecular mechanisms underlying their actions remain unclear. Understanding the neurological mechanisms that ...

Depicted are the hypothesized mechanisms of action of pharmacotherapies ... In the ambulatory setting, the usual prophylactic thiamine dose is 100 mg administered orally for 3 to 5 days.

The discovery and development of GLP-1 receptor agonists for type 2 diabetes and obesity is a bench-to-bedside success story.1 Multiple GLP-1 receptor agonists are now in clinical use, such as ...

Introduction: The cholinergic anti-inflammatory pathway regulates immune responses through the alpha7 nicotinic acetylcholine receptor (α7nAChR), found in neurons, macrophages, and monocytes. α7nAChR ...

An effort two decades in the making, Vertex Pharmaceuticals Inc.’s suzetrigine gained U.S. FDA approval as the first drug targeting the NaV1.8 pain signal. Branded Journavx, the oral small molecule is ...

A novel technique to identify and locate lipids in the brain The research group was able to understand the mechanism ... cannabinoid receptors were seen to be activated and the acetylcholine ...

We strive to develop medications that do only 1 or 2 things (ie, blocking serotonin reuptake or blocking D2 and 5HT2a receptors) and do nothing else. We assume that all other mechanisms of action ...