A recent meta-analysis reveals no link between pathologic complete response and long-term survival in rectal cancer, challenging its use as a surrogate endpoint.

“Thus, for upper rectal cancer, the trade-off between using [neoadjuvant radiotherapy] to pursue better oncological outcomes and creating diverting stomas to lower the risk of symptomatic leak ...

Total neoadjuvant therapy demonstrates consistent real-world efficacy across regimens in patients with locally advanced ...

Reply to: Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Omission of Radiotherapy or Not? The following represents disclosure information provided by authors of this manuscript. All ...

TAMIS is only possible in early-stage disease and most patients present with locally advanced rectal cancer (stage 2). To improve organ preservation and allow these patients to have a better quality ...

Cost-Effectiveness of Total Neoadjuvant Therapy With Selective Nonoperative Management for Locally Advanced Rectal Cancer: Analysis of Data From the Organ Preservation for Rectal Adenocarcinoma Trial ...

Upfront chemotherapy and radiotherapy may help reduce the need for surgery in patients with locally advanced rectal surgery, according to recent research. Not only can this treatment method decrease ...