A recent meta-analysis reveals no link between pathologic complete response and long-term survival in rectal cancer, challenging its use as a surrogate endpoint.

Background: Neoadjuvant chemoradiotherapy is currently the standard strategy for microsatellite stable (MSS) / mismatch repair-proficient (pMMR) locally advanced rectal cancer (LARC) patients. This ...

Total neoadjuvant therapy demonstrates consistent real-world efficacy across regimens in patients with locally advanced ...

“Thus, for upper rectal cancer, the trade-off between using [neoadjuvant radiotherapy] to pursue better oncological outcomes and creating diverting stomas to lower the risk of symptomatic leak ...

A new study published in the journal of BMC Surgery showed that robotic surgery for rectal cancer exhibits oncological and ...

Reply to: Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Omission of Radiotherapy or Not? The following represents disclosure information provided by authors of this manuscript. All ...

Upfront chemotherapy and radiotherapy may help reduce the need for surgery in patients with locally advanced rectal surgery, according to recent research. Not only can this treatment method decrease ...

Some of the goals of neoadjuvant therapy can be to reduce the tumor volume making the potential for a complete surgical resection more possible. Neoadjuvant therapy can also allow us to start treating ...

Cost-Effectiveness of Total Neoadjuvant Therapy With Selective Nonoperative Management for Locally Advanced Rectal Cancer: Analysis of Data From the Organ Preservation for Rectal Adenocarcinoma Trial ...