Results from a phase 1a/1b study of botensilimab (BOT), a novel innate/adaptive immune activator, plus balstilimab (BAL; anti-PD-1 antibody) in metastatic heavily pretreated microsatellite stable ...

particularly without any difference in survival outcomes between the two total neoadjuvant therapy regimens. We feel that induction chemotherapy-radiotherapy remains a viable treatment option for ...

Study: Total neoadjuvant treatment using short ... The RAPIDO (short for Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation) trial compared CRT with a TNT regimen ...

“The strategy is now investigated in rectal cancer for tailored management according to response to induction modified FOLFIRINOX.” A move toward total neoadjuvant therapy in rectal cancer has ...

Whether neoadjuvant chemotherapy with ... Alone or Chemotherapy Plus Radiation Therapy in Treating Patients with Locally Advanced Rectal Cancer Undergoing Surgery) to test the hypothesis that ...

A total neoadjuvant therapy (TNT) approach is strongly recommended for patients with T3 to T4 and node-positive rectal cancer undergoing neoadjuvant RT. TNT with chemotherapy before or after long ...

Here is the evolving role of radiation therapy in managing rectal cancer, highlighting the latest developments and their impact on patient care. 1. Neoadjuvant Radiation Therapy: Neoadjuvant ...

Key recommendations include the following: Neoadjuvant radiation therapy is recommended for patients with stage II or III rectal cancer to reduce their risk of locoregional recurrence. A thorough ...

Adjuvant therapy can be more ... Ovarian cancer. Neoadjuvant chemotherapy is a treatment for late-stage ovarian cancer. You might get it before surgery. Rectal cancer. You may get chemotherapy ...

guidelines for locally advanced rectal cancer treatment endorse watch-and-wait for patients with clinical complete response after neoadjuvant therapy,” said Zhao. “Our protocols follow established ...