Background: Interim results of the randomized phase II trial of neoadjuvant tislelizumab +/- oral APL-1202 (nitroxoline) revealed promising pathological complete response (pCR) rates and met ...

Among patients with nonmetastatic, muscle-invasive bladder cancer (MIBC), treatment with neoadjuvant cisplatin-based combination chemotherapy (NAC) plus bladder-saving concurrent chemoradiation ...

Patients were randomly assigned to receive either neoadjuvant mitomycin C or no neoadjuvant therapy (control arm) prior to TURBT. In the experimental arm, patients underwent cystoscopy and tumor ...

Meeting Coverage > GuCS Expert Video Roundtable Latest on Neoadjuvant Immunotherapy in Muscle-Invasive Bladder Cancer — Matthew Galsky, MD, leads a discussion with Guru Sonpavde, MD, and John ...

Bladder Preservation in Muscle-Invasive Bladder Cancer. ... [to neoadjuvant therapy]," study author Daniel Geynisman, MD, of Fox Chase Cancer Center in Philadelphia, told MedPage Today.

In the neoadjuvant and adjuvant phases of arm C, pembrolizumab will be administered on day 1 and enfortumab vedotin will be administered on days 1 and 8 of each cycle. Enrollment is complete for arm A ...

A new study published in the British Journal of Urology International found that sarcopenia was linked to increased the risk ...

References: Imfinzi ® (durvalumab) approved in the US as first and only perioperative immunotherapy for patients with muscle-invasive bladder cancer. News release. AstraZeneca. March 31, 2025 ...

Neoadjuvant chemotherapy followed by radical cystectomy is the standard treatment for cisplatin-eligible patients with muscle-invasive bladder cancer. Adding perioperative immunotherapy may ...

And, with 1063 participants, it is the largest study ever undertaken in muscle-invasive bladder cancer, noted Powles. The patient population had classic muscle-invasive disease (clinical tumor ...

The American Cancer Society estimates that 83,000 new cases of bladder cancer will be diagnosed this year, with almost 17,000 fatalities. A new gene therapy is giving patients more hope of ...